We are very happy that he decided to form a company focused on leading-edge technologies with transformative potential, assembled a great team of seasoned drug hunters and chose to collaborate with us, on both target discovery and generative chemistry", said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. Strategies to overcome acquired resistance to EGFR TKI in the treatment of non-small cell lung cancer. Clin Transl Oncol. The lead product - Zorifertinib, with 100% BBB penetration, is the next-generation EGFR TKI drug especially designed for treatment in EGFR mutation positive advanced NSCLC patients with central nervous system metastases, which is the first-in-class drug and supported by national funds as National Major Project for New Drug Innovation of China. Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone The Registered Agent on file for this company is CT Corporation System and is located at 155 Federal St., Ste. "Most of the pharmaceutical and biotechnology companies these days are working more or less on similar well-known targets and the innovation is in new molecular structures. Redx makes the most of Jounces demise, but is the poor reputation of reverse mergers warranted? AllianThera Biopharma headquarter office and corporate office address is located in 4-B101-125, Creative Industry Park, No. Win whats next. 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Cells 2018;7:212. We are very happy to collaborate with Insilico Medicine which has unique capabilities in target discovery and generative chemistry," said Yuan-Hua Ding, PhD, Co-founder and CEO of ATB. Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep knowledge in Immunology and Oncology and drug discovery expertise with partners' technologies while leveraging unique strengths in different geographies, East or West. In an allogenic humanized mouse model, CD73 deletion enhanced immunogenicity of MET-amplified, EGFR-TKI-resistant cells, and PEM treatment promoted robust responses regardless of CD73 status. 700, Boston, MA 02110. Piper Companies is always on the lookout for new talent. Epub 2016 Sep 9. are not responsible for the accuracy of news releases posted to EurekAlert! Now, says Dr. Levitt, Insilico Medicine is using AI to create an entirely new AI-driven drug discovery pipeline from A to Z. Careers. BioPharma Companies are Investing $3 Billion in our Region Find Out Why Biopharma manufacturers have been thriving here for decades and recent growth confirms what we've known for many years this is a great place for business! -, Le X, Puri S, Negrao MV, Nilsson MB, Robichaux J, Boyle T, et al. Impaired T-cell antigen-specific recognition of HCC827-GR6 cells despite elevated STING. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and drug experiences with partners' technologies while leveraging unique strengths in different geographies, East or West. We are looking for team players who collaborate, communicate and innovate. We are very happy that he decided to form a company focused on leading-edge technologies with transformative potential, assembled a great team of seasoned drug hunters and chose to collaborate with us, on both target discovery and generative chemistry," said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. . With several decades of combined experience and successful multi-billion dollar deals, we have honed our formula to unlock future value powered by deep sector and capital markets knowledge, Closing of 138 Million Initial Public Offering, Ordinary Shares and Warrants will Commence Separate Trading. A biparatopic antibody-drug conjugate to treat MET-expressing cancers, including those that are unresponsive to MET pathway blockade. The company reckons it can succeed where other cell therapies have failed, but proof is a long way off. MET amplification upregulates CD73 to suppress tumor cell STING induction and T-cell responsiveness in TKI-resistant, EGFR-mutated lung cancer, identifying a strategy to enhance immunogenicity and improve treatment. Careers. Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Allianthera, Astrazeneca, Biontech, Immunoprecise, Isotopia, Istari, Kyowa Kirin, Lassen, Medicenna, Molecular Targeting, Nektar, Pfizer, Pieris, RDIF, Redhill, Seagen, Twist. See this image and copyright information in PMC. Integrated, Universal & Experimentally-Validated, Our mission is to accelerate drug discovery and drug development. AllianThera Biopharma (ATB) Life Sciences | Drug Development Southborough, MA Profile Website Alloplex Biotherapeutics, Inc Life Sciences | Drug Development Woburn, MA Profile Website Alloy Therapeutics Life Sciences | Drug Development Lexington, MA Profile Website Alnylam Pharmaceuticals, Inc. Life Sciences | Drug Development Cambridge, MA 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. by contributing institutions or for the use of any information through the EurekAlert system. Epub 2016 Jul 19. Clipboard, Search History, and several other advanced features are temporarily unavailable. ChinaBio Partnering Forum, the largest and most productive life science partnering event in China, offers multiple ways for you to be part of the event. Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer. In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. PMC Would you like email updates of new search results? AllianThera Biopharma Updated February 18, 2023 Popular Jobs on Glassdoor Mechanical Engineer Jobs IT Jobs Human Resource Jobs Healthcare Jobs Graphic Designer Jobs Account Executive Jobs Registered Nurse Jobs Pharmaceutical Sales Jobs Guide to Getting Your First Job Find a Great First Job to Jumpstart Your Career How to Get a Job 2009 Jul;10(4):281-9. doi: 10.3816/CLC.2009.n.039. Description. Our Pharma.AI platform has the potential to rapidly bring novel breakthrough medicines to patients . We take on biologically-validated targets that have been previously elusive but that have the potential to transform medicine. These data reveal that combined PEM and CD73 inhibition can co-opt tumor cell STING induction in TKI-resistant EGFR-mutated lung cancers and promote immunogenicity. For more than four decades, the SCT and its international membership have advocated for the use of clinical trials to inform science and advance human health and wellness. Terms were not disclosed. AllianThera Biopharma was founded in China. This site needs JavaScript to work properly. The latest edition of the PD(L)anner focuses on combinations, and analyses the difficulties China developers are having with US approvals. We are building a strong portfolio through internal R&D programs and external partnerships with an initial focus on unmet medical needs in immunology and cancer. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Diabetes is a chronic metabolic disease characterized by high blood glucose. . -. SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China -based startup focusing on inventing and developing innovative medicines for a broad range of. Founder of Allianthera Biopharma Co. and New England Structural Biology Association, Inc., Yuan Hua Ding occupies the position of Chief Executive Officer for Allianthera Biopharma Co. and Chief. The company's principal address is 11 Bantry Rd., Southborough . All content is posted anonymously by employees working at AllianThera Biopharma. Advanced Search Title. Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. Dr. Ding and Dr. Cote-Sierra together with Prof. Zhijie Liu, a well-known GPCR structural biologist at the ShanghaiTech University, co-founded ATB to combine deep disease biology and drug R&D know-how with breakthrough technologies to tackle difficult diseases with underline disorders in the immune system. Go to your account and send up to 300 emails per day using the Free plan. GSK shows that Cabenuva every two months is as good as daily Biktarvy, but Gilead looks to go even longer. Senior Scientist 5 jobs; AllianThera Biopharma Locations. Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. Before Dr. Ding and Dr. Cote-Sierra, each has 20+ years of R&D experiences and leadership roles in major pharmas, were former colleagues at Pfizer. Website http://insilico.com/. Learn More Natick, MA 2 jobs; Independence, KS 1 jobs; 9 Guanghua Road, Chaoyang District, Beijing. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and drug experiences with partners' technologies while leveraging unique strengths in different geographies, East or West. Chills in the biopharma M&A market are frequently blamed on the FTC. view more. What you see here scratches the surface Request a free trial The companies utilized a pipeline of Insilico Medicine's artificial intelligence platforms including PandaOmics to identify a list of promising targets in cancer and autoimmune diseases and prioritize novel high-confidence targets to progress into early-stage drug discovery. Search Jobs. Sorry, we didn't find any related vantage articles. Developer of GPCR-targeted drug. Founded in 2020. AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, have announced a collaboration to discover and develop molecules for novel targets in cancer and autoimmune diseases. The data displayed is available through open government websites and public online directory. -, Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, et al. 218 Xinghu Street, Suzhou, Jiangsu, CN, Jinshan Chen - General Manager, China R&D. Investors & Media. Cancer Lett. 2023 SignalHire.com is operated by SENDERSYSTEMS LIMITED, AllianThera Biopharma headquarters is in Suzhou, Jiangsu. Alpha Biopharma Specialize in drug innovation from clinical development to commercialization success. PEM-induced immunogenicity is restrained by CD73. Yuanhua Ding - AllianThera Biopharma (ATB) | ChinaBio Partnering Forum 2022 Speaker Yuanhua Ding Founder and Chief Executive Officer at AllianThera Biopharma (ATB) Agenda Sessions Innovating for tomorrow, innovating for the world On Demand View Session Speakers at this event Prev Next Tina Elder Global General Manager EBD Group polly.firs@insilico.com, Copyright 2023 by the American Association for the Advancement of Science (AAAS), /Life sciences/Biochemistry/Pharmacology/Drug development/, /Health and medicine/Clinical medicine/Medical treatments/Cancer treatments/, /Health and medicine/Medical specialties/Immunology/Immune disorders/. Landscape of EGFR-dependent and -independent resistance mechanisms to osimertinib and continuation therapy beyond progression in EGFR-mutant NSCLC. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been unsuccessful to date. 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In the recent past, Dr. Ding was Vice-President of Pfizer External Science & Innovation focusing on emerging sciences, promising products and innovative technologies in the Asia Pacific regions. Shanghai: Unit 04-08, 5F, Platinum Building, No.233, Taicang Road, Huangpu District, Shanghai, Beijing: Room 2512, The Place Tower, No. Primary Office 4-B101-125, Creative Industry Park, No. 13 Dana-Farber Cancer Institute, Boston, Massachusetts, United States. Jobs at AllianThera Biopharma. Suzhou-based AllianThera emerged from stealth this week with a discovery and development deal with AI play Insilico, undisclosed seed funding and a leadership team hailing from big pharma. Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, announced a collaboration to discover and develop molecules for novel targets in cancer and "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. AllianThera Biopharma lead by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases, image:AllianThera Biopharma collaborates on AI with Insilico Medicine. "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. Since its inception, Insilico Medicine raised over $52 million, published over 100 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards. 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Using a physiologic antigen recognition model, inactivation of CD73 significantly increased antigen-specific CD8+ T-cell immunogenicity following PEM treatment. Above is snippet of Google Trends for "Protein-Coupled Receptors" term, if you have problem loading the snippet, please visit here: Google Trend. Altimmune aims to build Momentum in obesity, Go or no go? Get involved to accelerate your cross-border partnering strategies. 328 Xinghu Street Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone Suzhou, Jiangsu China AllianThera Biopharma Timeline 2021 2022 Date Founded Financing Round Want detailed data on 3M+ companies? CD73 coactivation with STING in MET-driven EGFR-TKIresistant cells. Co-Founder & CEO at ATB (AllianThera Biopharma) Southborough, Massachusetts, United States 3K followers 500+ connections Join to view profile ATB (AllianThera Biopharma) University of. The company's File Number is listed as 001497025. alicia@thrustsc.com. 700 Technology Square, 5th Floor Cambridge, MA 02139 617.674.5100 At ATB we would like to focus on disease biology and to adapt different technologies to tackle mix of new targets and some completely radical targets that even big pharmaceutical companies consider too risky to explore. Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation. Disclaimer. In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. However, STING activation was restrained by ectonucleosidase CD73, which is induced in MET-amplified, EGFR-TKI-resistant cells. Dr. Cote-Sierra, an immunologist with strong drug discovery and early clinical development expertise acquired through his years at Millennium Pharmaceuticals (Takeda now), Roche and GSK, was recently the Head of Inflammation and Immunology External Innovation at Sanofi Partnering where he and his team contributed to multi-program collaborations and acquisitions. Company. A, TCR expression, CD73 coactivation with STING in MET-driven EGFR-TKIresistant cells. 2012 Oct;11(10):2149-57. doi: 10.1158/1535-7163.MCT-12-0195. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. Close Appointment form contact@ai-biopharma.com Categories Home Company Services Pipeline News & Events Contact and transmitted securely. image: AllianThera Biopharma collaborates on AI with Insilico Medicine. Federal government websites often end in .gov or .mil. Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment. Dr. Ding and Dr. Cote-Sierra together with Prof. Zhijie Liu, a well-known GPCR structural biologist at the ShanghaiTech University, co-founded ATB to combine deep disease biology and drug R&D know-how with breakthrough technologies to tackle difficult diseases with underline disorders in the immune system. They share a common passion in discovery and develop novel therapeutics for patients in need the most. view more Credit: Insilico Medicine. official website and that any information you provide is encrypted At Recludix, we are innovators and inventors. Show more AllianThera Biopharma headquarters is in Suzhou, Jiangsu. Please visit the vantage homepage for our latest articles or search our articles via the buttons below. ATB is a newly established biotechnology company led by seasoned drug hunters, Dr. Yuan-Hua Ding (CEO) and Dr. Javier Cote-Sierra (CSO), with seed money from Bohe Angel Fund, Anlong Venture and Kaitai Capital. Cd73 significantly increased antigen-specific CD8+ T-cell immunogenicity following PEM treatment headquarter office corporate... & # x27 ; s principal address is 11 Bantry Rd., Southborough 11 ( 10 ) doi... M & a market are frequently blamed on the FTC treatment of non-small cell lung cancer entirely. Account and send up to 300 emails per day using the Free plan both..., including those that are unresponsive to MET pathway blockade to date to create an entirely AI-driven... In MET-driven EGFR-TKIresistant cells bring novel breakthrough medicines to patients can succeed other! Public online directory integrated, Universal & Experimentally-Validated, our mission is to accelerate drug discovery pipeline from to! 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